Blar i Bergen Open Research Archive på forfatter "Siljan, William Ward"

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    • Hepcidin and Ferritin Predict Microbial Etiology in Community-Acquired Pneumonia 

      Oppen, Kjersti; Ueland, Thor; Siljan, William Ward; Skadberg, Øyvind; Brede, Cato; Lauritzen, Trine; Aukrust, Pål; Steinsvik, Trude; Husebye, Einar; Michelsen, Annika; Holter, Jan Cato; Heggelund, Lars (Journal article; Peer reviewed, 2021)
      Background Iron is crucial for survival and growth of microbes. Consequently, limiting iron availability is a human antimicrobial defense mechanism. We explored iron and iron-related proteins as potential biomarkers in ...

    • Hepcidin predicts 5-year mortality after community-acquired pneumonia 

      Oppen, Kjersti; Ueland, Thor; Michelsen, Annika Elisabet; Aukrust, Pål; Steinsvik, Trude; Skadberg, Øyvind; Brede, Cato; Siljan, William Ward; Husebye, Einar; Holter, Jan Cato; Heggelund, Lars (Journal article; Peer reviewed, 2022)
      Background Virtually all living organisms, including microbes and humans, depend on iron to survive and grow. During an infection, the plasma level of iron and several iron-related proteins change substantially. We ...

    • Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools 

      Siljan, William Ward; Sivakumaran, Dhanasekaran; Ritz, Christian; Jenum, Synne; Ottenhoff, Tom HM; Ulvestad, Elling; Holter, Jan Cato; Heggelund, Lars; Grewal, Harleen (Journal article; Peer reviewed, 2022)
      Background: Current approaches for pathogen identification in community-acquired pneumonia (CAP) remain suboptimal, leaving most patients without a microbiological diagnosis. If better diagnostic tools were available for ...

    • Nausea Predicts Bacteremia in Immunocompetent Patients with Pneumococcal Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort 

      Fløystad, Hans Kristian; Holter, Jan Cato; Husebye, Einar; Siljan, William Ward; Berild, Dag; Holm, Are Martin; Heggelund, Lars (Journal article; Peer reviewed, 2023)
      Background: In pneumococcal community-acquired pneumonia (CAP), bacteremia is associated with increased mortality, but initial clinical severity scores frequently fail to identify bacteremic patients at risk. We have ...

    • Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections 

      Dyrhovden, Ruben; Eagan, Tomas Mikal Lind; Fløtten, Øystein; Siljan, William Ward; Leegaard, Truls Michael; Bø, Bjørnar; Fardal, Hilde; Grøvan, Fredrik; Kildahl-Andersen, Arne; Larssen, Kjersti Wik; Tilseth, Rune; Hjetland, Reidar; Løes, Sigbjørn Suk; Lindemark, Frode; Tellevik, Marit Gjerde; Breistein, Rebecca Irene; Kommedal, Øyvind (Journal article; Peer reviewed, 2023)
      Background Many community-acquired pleural infections are caused by facultative and anaerobic bacteria from the human oral microbiota. The epidemiology, clinical characteristics, pathogenesis, and etiology of such ...